Chemspec Europe '93

06 January 1993 00:00  [Source: PCE]

The eighth Chemspec Europe Exhibition takes place on June 23-24,in Building 1, Messe Basel, Basel, Switzerland. Over 200 exhibitors will participate, from the US and japan, as well as Europe.

Biocides

Albright & Wilson Biocides Group manufactures a wide range of both active ingredients and formulated products, sold under the Tolcide trademark.

In addition to their traditional active ingredients - MBT, TCMTB, dazomet and chlorosulphone - Albright & Wilson has developed THPS, tetrakis hydroxymethyl phosphonium sulphate, a fast-acting, water soluble biocide, with good toxicological and environmental profile. It is available as the Tolcide PS range of concentrates and formulated products. TCMTB concentrate is now offered in an easy-to-handle form at 60% activity as Tolcide C60.

Fine Chemicals/Intermediates

Building on raw materials strengths in acrylonitrile, acrylamide and acrylic acid, Allied Colloids' Fine Chemicals Division has developed a portfolio of substituted ethylene diamines, other speciality amines including N,N-diisopropyl ethylamine (Hunig's base), nitriles and high performance monomers. The latest addition is a range of N-substituted piperidones, to be launched at Chemspec.

Associated Octel, and its subsidiaries, has interests across basic chemicals, petroleum additives, fine chemicals and specialities and is strong in raw materials (bromine, chlorine, sodium). Partnerships are an increasingly important element in expanding the Group's activities, where its products and manufacturing expertise can contribute to successful new developments.

BASF will be presenting a selection of products from its range of 700 intermediates, including an extensive selection of amines, diols, carboxylic acids and carboxylic acid derivatives. Of particular interest in the display will be:

• Special pyrrolidones, which are used, for example, in the electronics industry as solvents for photosensitive resists.
• Benzaldehydes, which are produced electrochemically and used primarily in the perfumes sector, as well as in the cosmetics and detergent industries.

Boots Chemicals operates within the Pharmaceuticals division of The Boots Company Plc. The group offers a range of bulk pharmaceuticals, fine chemicals and biocides and in addition, contract production of speciality chemicals for a wide range of industries.

A facility offering specialised services associated with the purification of macromolecules is available, including preparative chromatography, freeze drying and centrifugation, all in a purpose built, controlled environment.

Within the chemicals group Boots MicroCheck is a unit dedicated to providing antimicrobial technology in the form of biocides, preservatives and detection services.

Courtaulds Chemicals, a division of Courtaulds plc, brings together the cellulose, acetyl related chemicals, flame retardants and pharmaceutical intermediates.

Esters are produced in Leek, Staffordshire. Main product areas include: acetates, chloroacetates and general chemicals used as plasticisers, surfactants, pharmaceutical and agrochemical intermediates. A major development is the production of aroma chemicals for the fragrance industry. Products include phenyl ethyl alcohol, benzyl acetate and a range of aldehydes.

Pharmaceutical intermediates are produced at Buckhaven, Scotland. A new five-vessel pharmaceutical production plant enhances the company's position as a leading supplier of trityl chloride.

DSM Andeno is part of the Fine Chemicals division of the multinational group DSM, with production locations in the Netherlands, Germany, Switzerland and Chile and sales offices in the Netherlands, US, Japan and France.

DSM Andeno offers pharmaceutical intermediates and bulk actives (on request) produced by a wide range of technologies including optical resolutions, biocatalysis, asymmetric synthesis, aromatic chemistry, Friedel-Craft reactions, Grignards, reactions in liquid ammonia, iodide chemistry and deep cooling.

Eastman Fine Chemicals specialises in the research, development, manufacture, sale and distribution of fine chemicals into the pharmaceutical, agrochemical, photographic and industrial chemicals markets. In addition, it can offer research chemicals and products to the laboratory market for both chemical and bio-science use.

The company offers substantial custom manufacturing sites, pilot plants and R&D facilities in Newcastle upon Tyne and Kirkby (UK), Chalon (France), Rochester and Rensselaer (New York), Kingsport (Tennessee), Batesville (Arkansas).

Eastman Fine Chemicals offers over 100 products and 50 chemical reactions and technologies.

Hoechst AG will be participating with its Fine Chemicals business unit. Also present will be Plüss-Staufer AG (which represents Hoechst AG's Fine Chemicals in Switzerland) and Sociéé Française Hoechst.

Besides its traditional aromatic intermediates, Hoechst AG Fine Chemicals will be particularly interested in discussing customers' requirements for new sophisticated intermediates for future developments.

Hüls produces a wide range of organic intermediates and fine chemicals, including building blocks for pharmaceutical and agrochemical materials, flavour and fragrance chemicals and precursors for plastics additives.

Main product lines comprise: alkaline alkoxides, alkyl chlorides, alkylaromatic compounds, cyano compounds, carbonylation products, heterocycles, malonic acid esters and derivatives, orthoesters and derivatives, oxidation products, hydrogenation products, flavour and fragrance materials and intermediates, plastics additives (hindered amine light stabilisers).

Hovione is an independent manufacturer of bulk active ingredients for the pharmaceuticals industry, special expertise in steroids and semi-synthetic tetracyclines.

The company has available 180m³ of reactor capacity for custom synthesis at its factories in Portugal and Macau.

Hovione offers stereospecific low/high pressure hydrogenation, halogenation, Grignard alkylation, fluorination, hydrofluorination, HF dehydration, preparation of new noble metal catalysts (eg rhodium) and their recovery.

Industry Chimique Mulhouse Donarch has facilities including a continuous nitration unit, amination, Bechamp reduction and multipurpose plants. R&D laboratories, plus pilot plant, develop several new products every year, mainly halogenonitroaromatics, nitroanilines, diphenylethers and organic fine chemicals for use in dyes and pigments, additives, agrochemicals and pharmaceuticals.

The following reactions can be undertaken by ICMD: nitrations, reductions, amination, condensations, alkylations, acylations, oxidations with HNO₃, hydrolysis, esterifications, halogenations (chlorination, iodination), cyclisations and diazotisations.

Katwijk Chemie BV, a completely independent company, works in the field of pharmaceutical fine chemicals and intermediates. A brand new production site complying with the latest environmental regulations and located in Katwijk, came on stream in the first quarter of 1992. Capacity here, using stainless steel and glass-lined reactors varying from 300 to 7000 litres, is available for new products and custom synthesis. Specialisation include cyanidation and condensation.

Laporte Organics - Fine Organics in the UK, Raylo in Canada and Peroxid Chemie in Germany - specialises in high quality pharmaceutical and agrochemical intermediates and polymerisation initiators. These include a range of multi-user products, such as oxalyl chloride, thiophosgene, methoxyamine hydrochloride, 4-nitrobenzyl bromide, carbonyl di-imidazole, 1,3-dichloroacetone and a range of DMT nucleosides.

Laporte Organics handles hazardous reagents, including carbon disulphide, dimethyl sulphate, chlorine, nitromethane and hydrogen peroxide, all in bulk. Process technology skills include photohalogenation, low temperature synthesis (to -70°C), phosgenation, chloromethylation, thiophosgenation and oranometallic, oxidation, peroxidation and epoxidation chemistry.

Lonza has recently expanded its fine chemicals business. Last year, it acquired the Riverside fine chemicals plant from SmithKline Beecham, making three fine chemicals facilities in the US market. Production of acetoacetate derivatives for the pigment and plant protection industries is concentrated at Bayport, the Los Angeles plant manufactures mostly middle volume generics and Riverside handles exclusive products on a one to ten tonne scale.

At Visp, the fourth production line has been started-up in the Fine Chemicals Complex. Lonza research has developed new key products for latest generation pharmaceuticals such as butylchloroimidazole aldehyde for angiotensin-ll antagonists, 6-chloropicolinic acid chloride and various pyrazine derivatives.

Macfarian Smith is Scotland's only independent manufacturer of organic intermediates and pharmaceutical actives, it is also the world's largest producer of opiate alkaloids. Both multi-stage chemical synthesis and extraction of natural material are used to produce over 50 chemical compounds.

Routine operations include hydrogenation, alkylation, borohydride reduction and the use of Grignard reagents and acid chlorides.

A recent $10m plant refurbishment ensures that all products are manufactured to the highest GMP level. A small scale manufacturing unit produces highly potent, low volume research pharmaceuticals in the 0.5-20kg range.

Heinrich Mack Nachf is a research and development based pharmaceutical company, with bulk pharmaceutical activities in three main areas:

• production of active pharmaceutical substances (antineoplastics, antivirals)
• production of intermediates to be used in the synthesis of drugs
• custom synthesis Special experience has been acquired with products based on multi-step synthesis, such as pyrimidine and purine derivatives and protected/unprotected sugar derivatives.

The manufacturing site in southern Germany is equipped with multi-purpose vessels of both glass enamel and stainless steel, volumes ranging from 100 to 3000 litre and suitable for pressures from 0-20 bar, temperature from -70 to +160°C.

The Merck Group, consisting of pharmaceutical and chemical manufacturing companies, owns manufacturing facilities in 43 locations worldwide. Business is divided into two main activities - pharmaceuticals and chemicals. The chemicals business consists of five divisions - reagents, diagnostics, industrial chemicals, pigments and fine chemicals.

At Chemspec, the fine chemicals division will be featured. This covers pharmaceutical raw materials, food additives, chemicals for optical fibres, electronics raw materials, photographic colour developers and general fine chemicals of high and guaranteed purity.

Nepera, a Cambrex company, features pyridine and pyridine derivatives, including 4-DMAP and its newest product, 3,5-lutidine. Speciality, fine and commodity chemicals manufactured by other Cambrex companies include alkenyl succinic anhydrides and bromo alkanes from Humphrey Chemical; a range of organic salts from Heico Chemicals; castor oil and fatty acids from CasChem, quaternary ammonium salts and para-aminosalicylic acid from Zeeland Chemicals and sulfasalazine USP from Salsbury Chemicals, which also has aresenic handling ability.

Nipa Laboratories Ltd, a member of the Biocides Division of BTP Plc, operates on four sites throughout the UK:

• The Sandycroft site in North Wales specialises in bulk active pharmaceuticals, including isosorbide dinitrate/isosorbide mononitrate, salicylate esters and p-hydroxy benzoic acid.
• The Oswaldtwistle site covers chlorination technology, including elemental chlorine, thionyl chloride, sulphuryl chloride, sulphur mono-chloride and sulphur dichloride.
• Cadishead has expertise in hydrogenation and esterification. A range of high pressure batch autoclaves makes up a flexible hydrogenation facility.
• The South Wales site produces a range of Parabens (p-hydroxy benzoic acid esters, including methyl, propyl, benzyl). Also an extensive range of organic intermediates for application in the reprographic, pharmaceutical and fine chemicals industries.

In Belgium, OmniChem, part of Japan's amino acid major, Ajinomoto, is active in the industrial development of complex amino acid derivatives within the Ajinomoto group. Additionally, the company handles diverse and highly specialised technologies at its production facilities at Louvain-la-Neuve, Wetteren and Balen. A section of its multipurpose facilities is specially designed for difficult or sensitive reactions. OmniChem offers a wide range of tetrazoles and thiadiazoles, mainly to the pharmaceutical industry. The facilities are also fully equipped for recovery and recycling of spent acids.

In the custom synthesis/toll manufacturing field, OmniChem focuses on special reactions, such as azide, peracid oxidation, nitration and organometallic reactions. Special expertise is claimed in alkaloid chemistry and the chemistry of natural botanical substances.

Peboc Ltd is a wholly-owned subsidiary of Solvay Duphar BV, part of the multinational Solvay et Cie.

Peboc's activities comprise the manufacture of Vitamin D₃ products, pharmaceutical ingredients and an expanding range of sophisticated pharmaceutical intermediates. Peboc will also be presenting a number of interesting new developments. These include:

• The latest additions to its range of high purity, peptide synthesis intermediates customers in the pharmaceutical industry, including: protecting agents, protected amino acids, coupling and activating agents.
• A range of versatile, protected chiral cyanohydrins and the derived, optically pure, pharmaceutical building blocks.
• Ingredients for use in thermochromic liquid crystal formulations.

Robinson Brothers Ltd' operations are carried out at two separate fully serviced sites in the UK, West Bromwich (near Birmingham) and Cambois (near Newcastle-upon-Tyne). Production scale varies from kg quantities up to some 500 tonne/year.

A major investment in multi-product plant is now in place at Cambois. Flexible 4500 litre glass-lined vessels with full services have been installed alongside facilities for segregated solids handling, including enclosed filter driers and laminar flow transfer booths.

SAF Bulk Chemicals, the industrial division of Sigma, Aldrich and Fluka Companies, offers an extensive range of biochemicals and fine chemicals. Details will be available on a range of specialities, including chiral intermediates, reagents for organic synthesis, biochemicals for biotechnology and raw materials for diagnostics manufacture.

SEAC, the fine chemicals subsidiary of the French group CFPI, specialises in pharmaceutical and photographic intermediates and active ingredients, mainly by multi-step synthesis of complex molecules.

SEAC R&D is also experienced in establishing synthetic routes for new compounds, from laboratory to full production.

SEAC's plant at Beuvry-La-Foret, near Lille in the north of France, has a full range of stainless steel and glass-lined reactors, capable of most standard reactions, including low and high pressure hydrogenation. Ancillary process equipment provides for purification by distillation, centrifuge, crystallisation etc, and includes a new solids conditioning and drying line.

Siegfried Chemie AG (Siegfried Chemicals) is part of a large group of companies, Siegfried AG, wholly Swiss-owned and headquartered in Zofingen, Switzerland. Its main products are pharmaceutical bulk active ingredients. It is represented in the US by Ganes Chemicals Inc, which operates two chemicals plants in New Jersey, by Siegfried Chemicals Inc in Taiwan and in Germany by Synopharm, a trading and distribution company. Custom manufacturing services are of increasing importance and include classic organic chemical reactions.

Sipsy is a fine chemical company, with expertise in the field of reduction. At present, Sipsy is the largest consumer of LiAlH₄ in the world. It is also prepared to work on other metal hydride reducing agents, such as Vitride and Dibal, as well as Diborane.

Sipsy has embarked on a programme called Redasym, aimed at developing various chiral reducing agents, such as Corey's catalyst. Sipsy is already producing pilot quantities of (R) and (S)-diphenyl prolinol, precursors of Corey's catalysts. It is also developing other asymmetric chemistry, such as alkylation and oxidation and is the exclusive manufacturer for Arco of chiral glycidols.

Sumitomo Corporation is a key member of the Sumitomo Group. The company will be exhibiting the following products:

• Sumitomo Chemical Co Ltd - cresol derivatives, resorcinol derivatives, optical active compounds, such as cyclopentone, various custom syntheses
• Koei Chemical Co Ltd - pyridines, piperidines, pyrrolidines, pyrazines, piperazines and other amines
• Sumitomo Seika Chemicals Co Ltd - thiophenol, thioanisole, tribromethyl, phenylsulphone
• Sumika Fine Chemicals Co Ltd - pyrimidines, purines, various custom syntheses, folic acid
• The Nippon Synthetic Chemical Industry Co Ltd - imidazol derivatives, alpha carboxylic acids and esters, aromatic carboxylic acids and esters, aldehydes and acetals.

Sumitomo Corp recently established a new company, Summit Chemicals Europe GmbH, in Germany, to promote sales service and expertise to the pharmaceuticals industry.

Since 1988, Synkem, Fine Chemical Division of the Fournier Group, located in Chenôve (Dijon, France) has increased its presence in the international market, becoming a custom manufacturer of organic chemicals for pharmaceutical, cosmetic, veterinary and high tech industries.

Synkem can carry out the scaling-up and industrialisation of new molecules or can become an alternative supplier in manufacturing molecules already on the market.

SNPE Chimie, the chemical division of the SNPE Group, offers active materials and synthesis intermediates conceived and manufactured according to its own fine chemistry synthesis processes: phosgenation, hydrogenation, nitration, electro-chemistry.

SNPE Chimie and its industrial subsidiaries, Isochem (organic synthesis for pharmaceutical industry) and Propeptide (an extensive range of amino acid derivatives for the synthesis of peptides), shows basic, fine and specialised chemistry in agrochemical and pharmaceutical fields.

SNPE Chimie will also feature oxalyl chloride and its derivatives. This product, produced and marketed by Chemilyl (50/50 joint venture SNPE/Tessenderlo Chemie) is mainly used in pharmaceuticals and agrochemicals.

Tessenderlo Chemie is an integrated group for the production of synthetic organic products at its five plants:

• Tessenderlo (B) - benzylchloride, benzylidene chloride, benzotrichloride, glycine and derivatives.
• Loos (F) - oxalyl chloride and its derivatives
• Maastricht (NL) - benzyl alcohol
• Farchemia (I) - bulk active ingredients for the pharm/veterinary industry, pharmaceutical intermediates.
• Calaire (F) - substituted and non-substituted phenylacetonitriles and derivatives, pharmaceutical intermediates

Tessenderlo Chemie also performs toll manufacturing production under secrecy or exclusivity agreement.

UBE Industries Ltd/UBE Europe GmbH is an innovative, R&D driven Japanese chemical company, which supplies intermediates, using its own nitrite chemistry, based on a UBE proprietary palladium-alkyl nitrite catalyst system. It supplies intermediates such as methyl-3-methoxyacrylate, 3-3-dimethoxypropionitrile, 3-methoxy-acrylonitrile, ethyl-3-dimethylaminoacrylate, dimethyl-1, 3-acetonedi-carboxylate, 4,4-dimethoxy-2-butanone and others. These have applications including key intermediates for 5- and 6-membered heterocyclics. Other new technology enables UBE to supply a variety of -keto esters, including methylisobutyrylacetate and methylpivaloyacetate.

Wacker core technologies include ketene/diketene chemistry, production of chloro carbonyl compounds and of components for the synthesis of hetero-cyclic compounds. The company is currently looking at applications of organometallic compounds and its knowhow in custom synthesis technology.

Contract R&D

Palmer Research offers contract research, development and manufacturing services to the chemical and pharmaceutical industries, specialising in complex advanced intermediates and products, requiring high levels of technical expertise, from laboratory research to manufacture, in reactors up to 2500 litre capacity. Specialist expertise includes bromination, chlorination, fluorination, photochemical and cryogenic reactions.

Inveresk Research International Limited provides comprehensive service in biological safety evaluation, custom designed to ease the path of a new chemical from the laboratory through to the marketplace:

• Review and evaluation of existing data
• Advice on testing requirements, including representation to appropriate regulatory bodies
• Cost effective test programme design and implementation
• Physico-chemical, toxicology and ecotoxicology studies for limited announcements, base sets and level 1 & 2 testing
• Preparation and submission of notification dossiers

Plant & Equipment

Buss AG builds high performance reactors, in particular for catalytic hydrogenations and ethoxylations. Most Buss reactor plants are purchased by the producers of fine or speciality chemicals, where versatility and improved product yields are specially important. The company can provide a comprehensive process development service, both on the laboratory and pilot scale.

Buss also builds phosgene generation plants, specially for the fine and speciality sectors and has developed its smallest plant to date, with an output of 10 to 100 kg/h of phosgene.

Pressindustria Group of Milan, Italy, operates worldwide in the R&D, engineering design and construction of plant and process equipment in the field of fine chemicals, such as:

• Ethoxylation (nonionic surfactants)
• Propoxylation (polyether polyols).

Solvent Recovery/Processing

Chemical Manufacture & Refining Ltd was formed by the management buyout of Gelpke & Bate Processing, with its three solvent recovery plants and storage facilities at Rye, Sunderland and North Shields. It offers:

• Toll processing - by-products and intermediates are refined by distillation processes to customers' specifications.
• the purchase/removal of contaminated solvent mixtures and byproducts for processing.
• the sale of the resultant recovered solvents to guaranteed specifications for re-use in a variety of industries.
• the storage of customers' products and mixtures in tanks, bonded and licensed when required, for hydrocarbons, methylated spirits and ethanol.
• the disposal of those wastes too badly contaminated to be recycled, by high temperature cement kiln incineration.

Chiral Chemistry

Chiros uses its technology base to access synthetically versatile chiral synthons for the pharmaceuticals industry. These enantiomerically pure intermediates can be supplied to an extremely high and consistent analytical specification and to match the requirements of pharmaceutical R&D. Areas of expertise include:

• The homochiral (+) and (-)-gammalactams, used to access the carbocyclic nucleoside antivirals.
• A variety of novel (+) and (-)-gamma-lactam derivatives.
• Unusual D- and L-amino acids for the synthesis of novel peptides and peptidomimetics.
• Lactone and chiral alcohol synthons for the preparation of HMG CoA reductase inhibitors.
• Novel homochiral oxygenated ring synthons used in novel antibiotics and antivirals.

Contract Manufacture

Contract Chemicals Ltd is an independent manufacturer of speciality fine organic chemicals. Amines, amides, acid chlorides and chloroalkyl amine hydro-chlorides are the company's strengths. Key products include thiocyanates,2-acetyl furan, sodium-2-ethyl hexanoate and trichloroacetamide. Benzophenone hydrazone and potassium 2-ethyl hexanoate are available to order.

New products include substituted benzophenones, benzhydrol, guiaicolglycidyl ether and a range of amines, including 3-NN-dimehtylaminopropyl chloride; dimethylamino ethyl chloride and dimethylamine. The award-winning Envirocats supported reagents offer significant environmental benefits over traditional catalysts.

Fisons Chemicals' recent modifications to production facilities include: distillation in all-glass equipment at high vacuum (5mbar) and high temperature (180°C), large batch (to 3000 litre) solvent production, pilot plant facilities for multi-step production, with capacities up to 100kg.

New products include: 2-chloroethylamine hydrochloride (pharmaceutical intermediate), Lithium dodecyl sulphate (electrophoresis grade) and iso-Hexane (HPLC), as an alternative to the neurotoxic solvent, n-hexane.

The main activities of the Haltermann organisation are based on its traditional strengths:

• toll and contract processing as a service to the chemical and allied industries.
• the production and distribution of aliphatic solvents as well as specialities based on hydrocarbons and natural, renewable raw materials.

Plants in Kallo, Belgium; Houston, Texas; Speyer and Hamburg, Germany, as well as tank farms in Koge, Denmark and Malmo, Sweden. Product modification for special applications is an essential part of the company's marketing organisation.

Ubichem offers its clients a comprehensive custom manufacturing service, from literature search, feasibility studies, bench scale synthesis, process development, pilot scale synthesis up to production level.

Close links to academia and research institutions ensure access to new technology. Special expertise is offered in: bromination, asymmetric synthesis, heterocyclic synthesis, fluorination, esterification, Grignard chemistry.

Hazardous Reactions/Nitration

Dynamit Nobel, a leading manufacturer of explosives, produces high quality intermediates, via hazardous reactions with explosive interim stages not suitable for standard plants. Dynamit Nobel runs these reactions safely with trained specialists, plants with special precaution facilities, research capacity and laboratories for material safety check-up and offers custom manufacturing in this area.

Specialities:

• Nitrogen compounds: azides, organic/inorganic, tetrazoles, triazoles, thiadiazoles, nitrates, technical/pharmaceutical, nitroso compounds, nitro compounds, nitro methane derivatives, azo compounds, hydrazides, optical active amine.
• Halogen compounds: of fluorine, chlorine, bromine.
• Applications: additives for petrochemicals, antibiotic side chains, biocides, blowing agents, dyes.

EMS Dottikon AG (formerly SSF Dottikon), also with a background of explosives manufacture, specialises in organic intermediates for pharmaceuticals, agrochemicals, additives, dyes and pigments, flavours and fragrances, photochemicals etc. Emphasis is placed on developing new intermediates, using expertise in nitration, catalytic hydrogenation, oxidation, condensation, cyclisation, pressure reactions and handling strong mineral acids, (all-glass spent acid recovery plant).

Exchem Industries produces chemical intermediates for the fine chemical, pharmaceutical, agrochemical, dye-stuffs and pigment industries. The company is also a major producer of alkyl nitrate additives for diesel fuel. Manufacturing is again based on experience in the explosives industry and specialties include nitration and nitric acid oxidation technology, using continuous or batch processes.

Phoenix Chemicals Ltd was established by Dr Derek R Palmer, formerly of Palmer Research, for the specialist handling of hazardous materials. Current projects include chloromethylation and the use of bis-chloromethyl ether (CIMAH schedule 3) and anhydrous hydrogen fluoride. This chemistry is used in the production of pharmaceutical intermediates, ion exchange resins and other selective syntheses.

Its new, purpose-built R&D laboratories are capable of handling the most hazardous of organics without any unacceptable risks to the environment.

Inorganics

Esseco is the largest Italian manufacturer of sulphur dioxide and derivate salts, with 70 years' experience in inorganic chemistry. Esseco has recently expanded and diversified its range of products to include the food industry, photography, oenology, paper chemicals, textiles, tanning and water treatment. Today, Esseco, occupies a site of 65 000m², with over 100 000 tonne/year production.

Lithium

The Lithium Division of Chemetall GmbH has used its know-how of handling and using air-sensitive products as the basis for a successful diversification into reactive derivatives of sodium, magnesium and other metals. The company offers:

• Lithium & lithium salts: Lithium metal - technical grade, battery grade, alloy grade in the form of powder, dispersion, granules, cones, rods, foils. Lithium salts - amide, benzoate, bromide, carbonate, chloride, fluoride, hydroxide, iodide, nitrate, perchlorate, tetraborate.
• Organolithium compounds: n-, sec-, tert-butyllithium, n-hexyllithium, methyllithium, phenyllithium, lithium acetylide-ethylendiamine complex.
• Hydrides: lithium aluminium hydride, lithium borohydride, lithium hydride, sodium borohydride, sodium hydride, catecholborane (1,3,2-benzodi-oxaborol).
• Alcoxides: Lithium tert.-butoxide, lithium methoxide, lithium-i-propoxide, sodium tert.-amexide, sodium tert.-butoxide, sodium i-propoxide.
• Organomagnesium compounds: Ethyl magnesium bromide, methyl megnesium choride, phenyl magnesium chloride, vinyl magnesium chloride.
• Miscellaneous: Ortho-amino benzyl alcohol, cyclopropyl carbinol, diethyl zinc, lead tetraacetate, sodium tert-butylcarbonate.
• Custom reactions: Reductions with complex hydrides, organometallic reactions.

Fluorochemistry

EniChem Synthesis SpA is the fine and speciality chemicals sector in the EniChem Group. Through Miteni, a joint venture with Mitsubishi Corporation, EniChem Synthesis operates in the field of fluoroderivatives. Miteni is active in fluorine chemistry, with technologies in diversified areas of advanced fluorochemical intermediates and high performance products.

Product lines include organic intermediates for pharmaceuticals, food industry, dyestuffs and agrochemicals, performance chemicals for the polymer industry, petrochemical industry, coatings and cosmetics.

Solvay Fluor and Derivate GmbH is part of the Solvay Deutschland group. Main activities are a wide range of fluorine compounds and allylchloride, epichlorhydrin and synthetic glycerin, as well as glycerin oligomers, including:

• Organic fluorine compounds: trifluoroacetic acid, trifluoroethanol, trifluoracetic acid ethylester, trifluoroaceticanhydride, trifluoroacetylchloride, trifluoroacetamide, n-fluorosulphonamide and a.m.o.
• CFC-substitutes like Solkane 123, 141b, 142b, 134a.
• Inorganic fluorine compounds: ammonium bifluoride, ammoniumfluoride, barium fluoride, cryolite, synth. powder, potassium bifluoride, potassium fluoroborate, sodium bifluoride, iodine pentafluoride, elemental fluorine.
• Polyglycerin and derivatives of glycerin: diglycerin, triglycerin and polyglycerin of various compositions special fatty acid esters of diglycerin, triglycerin and polyglycerin, as emulsifiers in food and cosmetics.
• isopropylidenglycerin, monoisopropylidendiglycerin, diisopropylidentriglycerin and other derivatives.

Bromine Chemistry

Great Lakes Chemical Corporation, based in West Lafayette, Indiana, claims to be the world's leading producer of bromine, brominated speciality chemicals and furfural additives.

The company's European subsidiary, with production facilities in the US, UK, France and Germany, offers fine organic chemicals for the pharmaceutical, agrochemical and other industries.

The production facility at Konstanz, Germany, manufactures pharmaceuticals, bulk actives and intermediates.

QO Chemicals Inc will show the latest developments and applications of furfural chemistry in synthesis and the possibilities of manufacturing sophisticated fine chemical products from the highly reactive furan ring. This year, QO will introduce newly developed furan-based solvents, with applications in agrochemicals and rubber.

Cyanide Chemistry

Hampshire Chemical is a new company formed by the management-led buyout of WR Grace's Organic Chemicals business (previously known in Europe as Grace Rexolin), with two principal operating units, in the UK and the US.

The UK business, specialises in cyanide chemistry, in three product areas: fine chemical intermediates, chelating agents (EDTA, NTA etc) and their derivatives (chelated metal micro-nutrients, photographic processing bleaches) and fatty acid sarcosinate surfactants.

The cyanide-based fine chemicals intermediates business, includes nitriles, aminoacetonitriles, cyanohydrins, aminonitriles, hydantoins and derivatives. Custom synthesis of specialised nitriles or other cyanide-based intermediates is carried out for thepharmaceutical and agrochemical industries.

Catalysts

WC Heraeus GmbH specialises in:

• development and production of heterogeneous precious metal catalysts, for liquid- or gas-phase hydrogenation and dehydrogenation reactions
• catalysts for purification of fine gases and industrial gases.
• catalysts for diesel, gas and petrol engines for movable and stationary use.
• catalytic incineration systems.
• precious metal compounds, organometallic compounds, precious metal electrolytes, electrolytical cells for cathodic deposition of precious and non-precious metals from aqueous solutions.
• recovery and refining of precious metals from spent catalysts, solutions and galvanising baths, Pt/Rh alloys, laboratory equipment and crucibles, ion exchange resins, silver scrap, etc.

Waste Treatment

Hovione developed Greencycle Technologies to protect the environment, reduce consumption and minimise waste through systematic recycling.

Hovione's production of bulk active ingredients uses recycled solvents, re-cycled reagents and acids and recovers noble metal catalysts (from heterogeneous and homogeneous hydrogenations, aqueous/low boiling point solutions) with yields from 65-98%.

Environmental services range from R&D up to design/build/operate recycling solutions for the pharmaceutical fine chemicals industry. The waste recovery plant is available to study recycling solutions with third party waste.

Laboratory/Research Chemicals

Katwijk's subsidiary, De Rover Chemie BV, has experience in preparing chemicals such as:

• sophisticated chemicals from a standard production programme
• custom synthesis
• contract research
• preparation of 5-50kg amounts of development products

The Janssen Chimica catalogue contains detailed information regarding structure, physico-chemical characteristics and safety precautions on the company's organic, inorganic and biochemical products.

All Janssen Chimica products are tested at different stages in its own quality control laboratories. Its technical information department has built up a complete file of material safety datasheets, available on request.

Dr Theodor Schuchardt & Co, a subsidiary of E Merck, manufactures and supplies organic intermediates primarily for use in R&D. Schuchardt keeps approx 4000 items in quantities up to 200kg permanently in stock and therefore has the same quality readily available for laboratory scale. A bulk catalogue with more than 1500 items will be available at the stand on request.

Biotechnology

In 1992, Lonza's acquired a fermentation plant, located at Kourim, about 50km from Prague. Under the name Lonza Biotec, this business segment is dedicated to biological processes. It features two production lines, equipped with fermenters with capacities of 5 x 5m³ and 4 x 50m³ respectively, as well as the requisite ancillary equipment. Lonza Biotec offers custom bioprocessing, in addition to the usual chemicals toll manufacture. It will also implement biotechnological processes of its own on an industrial scale.

Orpegen GmbH has expertise in: Production and analysis of amino acid derivatives from kg to tonne quantities (tert. butylesters & ethers, Fmoc-, Boc-, Ddz-, Z-); development and production of pharma peptides from mg to kg (antigenic determinants, hormones, immunoregulatory fragments etc); recombinant protein by cell culture or fermentation, including GMP standards and protein refolding; development and production of diagnostic test kits for flow cytometry (Phagotest, Bursttest).

Orpegen undertakes contract research and services: on peptides and proteins (synthesis, sequencing, HPLC protocols protein analysis); in biotechnology (pharmaceutical grade proteins, recombinant proteins with mammalian cell lines, fermentation of genetically engineered bacteria and yeast, in microbiology (strain improvement, screening and mutagenesis of bacteria, flow cytometry of bacterial populations); in molecularbiology (DNA amplification, cloning, construction of expression vectors, sequencing, viral decontaminations, DNA trace determination etc); in cell biology and immunology (in vitro assays, in vivo model, preclinical studies and clinical monitoring by flow cytometry, polyclonal sera and monoclonal antibodies).

Petrochemicals/Storage & Processing

Paktank Industrial Distillation (PID specialises in upgrading petrochemicals byproducts into chemical specialities, special solvents, gasoline and gas-oil components, as recovery of contaminated materials and solvent recycling.

PID's laboratory develops, in cooperation with principals, chemical specialities and solvents on lab- and semi-technical scale. Samples of products are being used to open new markets.

In close cooperation with its mother company, Paktank International, PID offers package deals for processing, storage and distribution, at tanker terminals worldwide.

The activities of Phillips Petroleum Chemicals include exploration and production of oil and natural gas, the production of chemicals and plastics. Headquarters are located at Bartlesville, Oklahoma, US and the coordination centre for Europe and Africa is based at Overijse, Belgium.

At Tessenderlo, Belgium, the company runs a plant for the production of high quality organo sulphur compounds, including mercaptans, sulphides, polysulphides, thioalcohols and thioethers. The Speciality Chemicals division brings sulphur chemicals, gas odourants, alkyl aromatics, speciality olefins, pure hydrocarbons, Soltrol isoparaffinic solvents and reference fuels to the market worldwide.

Development is focused on sulphur chemistry, alkylation, olefin dimerisation, metathesis and hydrogenation, to bring new products to the market place, which meet special requirements.

Substituted Aromatics

Substituted aromatics are the speciality of Rohner. The company carries out custom manufacturing as well as production of a range of multistage products. Rohner's latest technical achievement, Reduction of nitroaromatics by Hydrogen Transfer Catalysis (HTC), is the new alternative to catalytic hydrogenation. Technological strengths are: the manufacture of substituted benzonitriles, such as 2-amino-benzonitrile, 4-amino-benzonitrile and their bromo- and chloro-derivatives, the innovative new approach in manufacturing aromatic sulfinic acids with a minimum of waste, and the diazotisation and subsequent reaction expertise within a dedicated plant. Emphasis is given to pharmaceutical intermediates, agrochemical intermediates, dyestuff and pigment intermediates, intermediates for the polymer additive industry, fine chemicals for the photographic industry and cosmetics.

Chemical Distributors

Scheller a leading Swiss distributor of industrial and speciality chemicals, represents many of the world's most important chemical producers worldwide.

Benfer-Scheller, headquartered in Milan, serves Italy, the second largest market for chemicals in Europe, three regional warehouses, Milan, Florence and Venice, supplying chemicals, raw materials, intermediates and specialities to major industries, including pharmaceuticals and surface coatings industries.

UK-based K&K Greeff markets additives and speciality chemicals for the rubber, lubeoil, plastics, pharmaceutical and surface coatings industries.

MB-Sveda is a Scandinavian distributor of solvents, plastics raw materials, industrial and speciality chemicals, with offices in Stockholm, Gothenburg, Norrkøping and Malmø. It has subsidiary companies in Finland, Norway and Denmark. All the above are Univar Europe companies.

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