08 April 2002 10:48 [Source: ICIS news]
LONDON (CNI)--Shares in Antisoma rose substantially on the London Stock Exchange (LSE) on Monday after the UK biopharmaceutical company announced that its cancer drug Thioplatin possesses properties distinct from those of other platin drugs and shows promising activity on cisplatin-resistant cells.
The research results were disclosed yesterday at the annual meeting of the American Association for Cancer Research in San Francisco, California.
Shares in Antisoma were up 8.8% at 21.5 pence at about 09:30 hours (08:30 GMT) on the London Stock Exchange (LSE).
Thioplatin was developed by scientists at the German Cancer Research Centre and in-licensed by Antisoma in October last year. It is a tumour-targeted version of a platin, a class of drugs that form the cornerstone of cancer treatments against a wide range of solid tumours, including lung, ovarian and testicular cancers.
Antisoma said that, although effective, the therapeutic dose for current platinum-based drugs is often limited by potentially serious side effects, including damage to the kidneys and small intestine. However, Thioplatin is designed to be more active in the acidic environment found around tumours, targeting and killing cancer cells and leaving healthy cells relatively undamaged, it explained.
Lloyd Kelland, Antisoma’s head of laboratory presented new data showing that Thioplatin was active in three human ovarian carcinoma cell lines with acquired cisplatin-resistance. Kelland also presented the results of work carried out at the US National Cancer Institute, which showed that Thioplatin has a unique cancer cell growth inhibition profile across a 60-human tumour cell line when compared with all other platinum compounds in the databank.
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