DSM Pharma Chemicals makes PLE breakthrough

29 January 2008 23:05  [Source: ICIS news]

NEW ORLEANS (ICIS news)--DSM Pharma Chemicals has isolated a highly effective isoform of a pig liver enzyme (PLE) called esterase and discovered a biotransformation route to manufacture this molecule on an industrial scale using a microbial host system, a company official said on Tuesday.

“This isoform really outperforms all the other isoforms [of PLE],” said Oliver May, competence manager biocatalysis & biotransformations, DSM Pharma Chemicals, who announced the breakthrough at InformexUSA.

DSM Pharma did not reveal the type of microbe it is using, such as yeast or bacteria. However, the implication was that it would give the pharmaceutical industry industrial-scale access to a highly potent biocatalytic enzyme that can be used to make pharmaceutical chemicals.

Moreover, it will be using a product that is not derived from an animal which is a critical factor for the pharmaceutical industry which is seeking to go “animal-free” with its ingredients, industry sources said.

The highly effective enzyme PLE plays an important role in the biocatalysis of pharmaceutical compounds. DSM Pharma tested PLE against more than 600 of its own enzymes and discovered that PLE outperformed all of those enzymes.

Despite initial setbacks, DSM Pharma realized that PLE is an enzyme that has potentially enormous applications in the pharmaceutical industry.

The company then undertook the labourious process of isolating the most effective isoform of the enzyme from pig liver cells.

After successfully isolating the most effective isoform, DSM Pharma managed to discover a new microbial host system that can reproduce it, which remains a closely guarded secret.

“We are not identifying the new host at this time,” May said.

The company is using the new system now to produce pharmaceutical PLE on a large scale.


By: Feliza Mirasol
+1 713 525 2653



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