LONDON (ICIS)--A French proposal to classify bisphenol A (BPA) as a presumed human reproductive toxicant which may damage fertility has been unanimously supported by the Risk Assessment Committee (RAC), the European Chemicals Agency (ECHA) said on Wednesday.
The RAC prepares the opinions of ECHA related to the risks of substances to human health and the environment. The final decisions are taken by the European Commission.
RAC wants to strengthen the existing harmonised classification and labelling (CLH) of BPA from a category 2 reproductive toxicant to a category 1B reproductive toxicant regarding the adverse effects on sexual function and fertility in line with a proposal from the French competent authority, the ECHA said.
After comparing available evidence with CLP criteria, the RAC concluded there were adverse effects on reproductive capacity (functional fertility) following oral exposure to BPA, a monomer mainly used in the production of polycarbonate plastics and epoxy resins, in a multi-generation guideline study in mice and in rats.
The ECHA said impaired female reproductive capacity was also seen in several supplementary non-guideline studies, and toxic effects in reproductive organs were observed in several studies.